DEBIO 1143

Research use only, not for human use.

DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.

DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively; effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines; effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors.Ovarian Cancer Phase 2 Clinical

AT-406;DEBIO1143;SM406;ARRY-334543;D1143

Others

Other Targets

cIAP1-BIR3;cIAP2-BIR3;XIAP-BIR3

Cancer

Ovarian Cancer

1071992-99-8

561.73

C32H43N5O4

>98% (HPLC)

DMSO: 93 mg/mL (165.6 mM); Ethanol: 93 mg/mL (165.6 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4

(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

(-20℃)

With Ice Pack

≥ 2 years